Acetonitrile → HCID 131715805, compound

HRID 2291320Notes

Reaction equation

HRID 2291320 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8][CH2:9][CH2:10][CH2:11]C#N)[N:3]=1.[F:14][C:15]([F:21])([F:20])[CH2:16][N:17]=[C:18]=[S:19].[C:22](#[N:24])C>>[F:14][C:15]([F:21])([F:20])[CH2:16][NH:17][C:18](=[S:19])[NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([S:8][CH:9]([CH2:10][CH3:11])[C:22]#[N:24])[N:3]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 138837771,1,1-Trifluoro-2-isothiocyanatoethaneHCID 21279726HCID 21279726, compound

Product 1

HCID 131715805HCID 131715805, compound

Procedure

A solution of 4-(2-aminopyrid-6-ylthio)butyronitrile (36 g.) and 2,2,2-trifluoroethylisothiocyanate (22 ml.) in acetonitrile (100 ml.) was left at room temperature for 18 hours. The crystalline precipitate was collected and washed with cold EtOH to give 4-[2-(3-[2,2,2-trifluoroethyl]thioureidopyrid-6-ylthio]butyronitrile, m.p. 131°-133°.

Workup

  1. customThe crystalline precipitate was collected
  2. washwashed with cold EtOH

Sources & evidence

ORD record
ord-4f35f14d5809445e8cce7da8126d050a
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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