Triethylamine → HCID 21279765, compound

Participants

Reaction Steps

To a solution of methyl 5-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-yl]valerimidate dihydrochloride (0.5 g.) in MeOH (10 ml.) was added triethylamine (0.125 g.) and cyanamide (0.08 g.) and the mixture was stirred for 18 hours at 20°. Volatile material was evaporated in vacuo and the residue was triturated with a mixture of ether and EtOH to give crude methyl N-cyano-5-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-yl]valerimidate as a white solid which was used without further purification.

Provenance & Evidence