Triethylamine → HCID 21279765, compound

HRID 2291322Notes

Reaction equation

HRID 2291322 reaction equation
Cl.Cl.[F:3][C:4]([F:25])([F:24])[CH2:5][N:6]=[C:7]([NH2:23])[NH:8][C:9]1[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][CH2:16][CH2:17][CH2:18][C:19](=[NH:22])[O:20][CH3:21])[N:10]=1.[CH2:26]([N:28](CC)CC)C.N#CN>CO>[C:26]([N:22]=[C:19]([O:20][CH3:21])[CH2:18][CH2:17][CH2:16][CH2:15][C:11]1[N:10]=[C:9]([NH:8][C:7]([NH2:23])=[N:6][CH2:5][C:4]([F:3])([F:24])[F:25])[CH:14]=[CH:13][N:12]=1)#[N:28]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 9864CyanamideHCID 21279819HCID 21279819, compound

Product 1

HCID 21279765HCID 21279765, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of methyl 5-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-yl]valerimidate dihydrochloride (0.5 g.) in MeOH (10 ml.) was added triethylamine (0.125 g.) and cyanamide (0.08 g.) and the mixture was stirred for 18 hours at 20°. Volatile material was evaporated in vacuo and the residue was triturated with a mixture of ether and EtOH to give crude methyl N-cyano-5-[4-(2-[2,2,2-trifluoroethyl]guanidino)pyrimid-2-yl]valerimidate as a white solid which was used without further purification.

Workup

  1. customVolatile material was evaporated in vacuo
  2. customthe residue was triturated with a mixture of ether and EtOH

Sources & evidence

ORD record
ord-e7ca4535f63a45b28b70c779a6163599
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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