Hydrochloric Acid → HCID 21279830, compound

HRID 2291336Notes

Reaction equation

HRID 2291336 reaction equation
[F:1][C:2]([F:20])([F:19])[CH2:3][N:4]=[C:5]([NH2:18])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16]#[N:17])[N:8]=1.Cl.[CH3:22][OH:23]>C(Cl)(Cl)Cl>[F:20][C:2]([F:1])([F:19])[CH2:3][N:4]=[C:5]([NH2:18])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[NH:17])[O:23][CH3:22])[N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21279856HCID 21279856, compound

Product 1

HCID 21279830HCID 21279830, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valeronitrile (2 g.) in MeOH (15 ml.) and chloroform (35 ml.) at 0° was saturated with HCl gas and the solution allowed to stand for 62 hours at 0°. The solvent was evaporated and the residue partitioned between aqueous potassium carbonate and chloroform. The chloroform extracts were washed, dried and evaporated to give methyl 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valerimidate as pale yellow oil.

Workup

  1. customat 0°
  2. customThe solvent was evaporated
  3. customthe residue partitioned between aqueous potassium carbonate and chloroform
  4. washThe chloroform extracts were washed
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-f2a2cb165352471d92064b119b981b68
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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