Acetohydrazide → HCID 178475142, compound

HRID 2291338Notes

Reaction equation

HRID 2291338 reaction equation
[F:1][C:2]([F:22])([F:21])[CH2:3][N:4]=[C:5]([NH2:20])[NH:6][C:7]1[N:11]=[CH:10][N:9]([CH2:12][CH2:13][CH2:14][CH2:15][C:16](=[NH:19])OC)[N:8]=1.[C:23]([NH:26][NH2:27])(=[O:25])[CH3:24]>CO>[C:23]([NH:26][NH:27][C:16](=[NH:19])[CH2:15][CH2:14][CH2:13][CH2:12][N:9]1[CH:10]=[N:11][C:7]([NH:6][C:5]([NH2:20])=[N:4][CH2:3][C:2]([F:1])([F:21])[F:22])=[N:8]1)(=[O:25])[CH3:24]

Participants

4

Reactant 2

HCID 14039AcetohydrazideHCID 21279830HCID 21279830, compound

Product 1

HCID 178475142HCID 178475142, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of methyl 5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valerimidate (0.5 g.) in MeOH (5 ml.) and acethydrazide (0.17 g.) was allowed to stand at room temperature for 3 hours. The solution was evaporated to give a sticky solid which was triturated with ether/EtOH to give N-acetylamino-5-[3-(2-[2,2,2-trifluoroethyl]guanidino)-1,2,4-triazol-1-yl]valeramidine as a white solid (0.71 g.), m.p. 157°-159°.

Workup

  1. customThe solution was evaporated
  2. customto give a sticky solid which
  3. customwas triturated with ether/EtOH

Sources & evidence

ORD record
ord-5eddcd1c899e4e34bc9c89bcd9f1b7ec
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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