Hydrochloric Acid → HCID 21279797, compound

HRID 2291341Notes

Reaction equation

HRID 2291341 reaction equation
[F:1][C:2]([F:21])([F:20])[CH2:3][N:4]=[C:5]([NH2:19])[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][C:17]#[N:18])[N:8]=1.Cl.[CH3:23][OH:24]>C(Cl)(Cl)Cl>[F:21][C:2]([F:1])([F:20])[CH2:3][N:4]=[C:5]([NH2:19])[NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([O:13][CH2:14][CH2:15][CH2:16][C:17](=[NH:18])[O:24][CH3:23])[N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21279728HCID 21279728, compound

Product 1

HCID 21279797HCID 21279797, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-yloxy]butyronitrile in a mixture of CHCl3 (10 ml.) and MeOH (5 ml.) was saturated with HCl gas at 0° and then kept at 0° for 3 days. The solution was evaporated to dryness and the residue shaken with a mixture of CHCl3 and aqueous K2CO3. The CHCl3 phase was dried and evaporated to dryness to give methyl 4-[2-(2-[2,2,2-trifluoroethyl]guanidino)pyrid-6-yloxy]butyrimidate (0.8 g.) which was used without further purification.

Workup

  1. customThe solution was evaporated to dryness
  2. dry with materialThe CHCl3 phase was dried
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-d73c4c6ffaf04a79bbab104eb2821754
Source dataset
uspto-grants-1989_01
Patent number
US04795755

Reaction notes

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