Bromine → 5-Bromo-4-chloro-6-phenylpyrimidin-2-amine

HRID 2291346Notes

Reaction equation

HRID 2291346 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:5]=[C:4]([NH2:14])[N:3]=1.[Br:15]Br>C(O)(=O)C>[Br:15][C:7]1[C:2]([Cl:1])=[N:3][C:4]([NH2:14])=[N:5][C:6]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 2408022-Amino-4-chloro-6-phenylpyrimidine

Product 1

HCID 143700575-Bromo-4-chloro-6-phenylpyrimidin-2-amine

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To 1.5 g (7.3 mM) of 4-chloro-6-phenyl-2-pyrimidinamine is added 75 ml of glacial acetic acid. This mixture is stirred to dissolve and 0.44 ml of bromine is added. The reaction is stirred at ambient temperature for 24 hours. The solution is evaporated to dryness under vacuum to yield 1.75 g of 5-bromo-4-chloro-6-phenyl-2-pyrimidinamine.

Workup

  1. dissolutionto dissolve
  2. stirringThe reaction is stirred at ambient temperature for 24 hours
  3. customThe solution is evaporated to dryness under vacuum

Sources & evidence

ORD record
ord-b39dacb255fa4c7fb341d9b2b46b86dc
Source dataset
uspto-grants-1989_01
Patent number
US04795812

Reaction notes

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