Hydrochloric Acid → HCID 21279981, compound

HRID 2291380Notes

Reaction equation

HRID 2291380 reaction equation
[ClH:1].[CH2:2]([O:9][C:10]([C:12]1[CH2:19][N:18]2[N:14]([C:15](=[O:28])[CH:16]([NH:20]C(OC(C)(C)C)=O)[CH2:17]2)[C:13]=1[C:29]([O:31][CH2:32][CH:33]=[CH2:34])=[O:30])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl>C(O)(=O)C>[ClH:1].[CH2:2]([O:9][C:10]([C:12]1[CH2:19][N:18]2[N:14]([C:15](=[O:28])[CH:16]([NH2:20])[CH2:17]2)[C:13]=1[C:29]([O:31][CH2:32][CH:33]=[CH2:34])=[O:30])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21279988HCID 21279988, compound

Product 1

HCID 21279981HCID 21279981, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere, allyl 3-(benzyloxycarbonyl)-7-(R,S)-(t-butoxycarbonylamino)-8-oxo-1,5-diazabicyclo[3.3.0]octa-2-ene-2-carboxylate hydrochloride (370 mg, 0.81 mmol) was combined with a 3N hydrochloric acid solution in glacial acetic acid (15 ml) and the solution was stirred at room temperature for 25 minutes. The acid was removed in vacuo and the remaining volatiles on the resultant residue were removed by azeotropic distillation with methylene chloride (2×) to give the title salt.

Workup

  1. customThe acid was removed in vacuo
  2. customthe remaining volatiles on the resultant residue were removed by azeotropic distillation with methylene chloride (2×)

Sources & evidence

ORD record
ord-2dd736592ba54894adef5f1c0f294942
Source dataset
uspto-grants-1989_01
Patent number
US04795815

Reaction notes

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