反应详情

A mixture of freshly distilled aniline (93 g, 1.10 mol), potassium carbonate (304 g, 2.2 mol), 6-chloro-1-hexanol (300.0 g, 2.2 mol), and 500 mL of η-butanol was heated at reflux for 82 hours under nitrogen with vigorous stirring. After cooling and filtering, the butanol was evaporated at reduced pressure to leave a tan oil. The oil was fractionally distilled in vacuo, yielding 205 g (70%) of A1 as a colorless oil, bp 195°-225° C. (0.15 nm).

1. temperaturewas heated
2. temperatureat reflux for 82 hours under nitrogen with vigorous stirring
3. temperatureAfter cooling
4. filtrationfiltering
5. customthe butanol was evaporated at reduced pressure
6. customto leave a tan oil
7. distillationThe oil was fractionally distilled in vacuo