Water → HCID 86742657, compound

HRID 2291452Notes

Reaction equation

HRID 2291452 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]#[N+:14][O-:15].[SH:16][CH2:17][C:18]([OH:20])=[O:19].[OH2:21]>C(COC)OC>[Cl:1][C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([Cl:12])[C:6]=2[C:13]([NH:14][O:15][S:16][CH2:17][C:18]([OH:20])=[O:19])=[O:21]

Participants

5

Reactant 3

HCID 962WaterHCID 1133Thioglycolic AcidHCID 15595595HCID 15595595, compound

Product 1

HCID 86742657HCID 86742657, compoundYield 81%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

12.0 g (50 millimoles) of 3,7-dichloroquinoline-8-nitrile oxide (compound No. 47) were suspended in 100 ml of dimethoxyethane, and 5.6 g (60 millimoles) of mercaptoacetic acid were added. The mixture was stirred for 6 hours at room temperature, after which it was freed from the solvent, water was added and the mixture was filtered under suction. 13.5 g (81%) of a product of melting point of 174° C. were obtained (compound No. 59).

Workup

  1. additionwas added
  2. filtrationthe mixture was filtered under suction

Sources & evidence

ORD record
ord-8e604d3d8da545e996094983c89fe490
Source dataset
uspto-grants-1989_01
Patent number
US04797148

Reaction notes

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