Water → Carboxymethylthio 3,7-dichloroquinoline-8-hydroxamate

Participants

Reaction Steps

12.0 g (50 millimoles) of 3,7-dichloroquinoline-8-nitrile oxide (compound No. 47) were suspended in 100 ml of dimethoxyethane, and 5.6 g (60 millimoles) of mercaptoacetic acid were added. The mixture was stirred for 6 hours at room temperature, after which it was freed from the solvent, water was added and the mixture was filtered under suction. 13.5 g (81%) of a product of melting point of 174° C. were obtained (compound No. 59).

Provenance & Evidence