Hydrogen Bromide → HCID 14373360, compound

HRID 2291533Notes

Reaction equation

HRID 2291533 reaction equation
[N+:1]([C:4]1[N:5]([CH2:9][CH:10]([OH:18])[CH2:11]C2N3C2CCC3)[CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].[BrH:19].[CH2:20](O)[CH3:21]>>[Br:19][C@@H:21]1[CH2:20][CH2:11][CH2:10][C@H:9]1[NH:5][CH2:11][CH:10]([OH:18])[CH2:9][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[N+:1]([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 21278819HCID 21278819, compound

Product 1

HCID 14373360HCID 14373360, compound

Procedure

α-[(Nitro-1H-imidazol-1-yl)methyl]azabicyclo[3.1.0]hexane-6-ethanol from Example 4 was ring-opened by the action of 2-3 equivalents of hydrogen bromide in ethanol to produce the title compound as the hydrobromide salt, mp 204°-205° C.

Sources & evidence

ORD record
ord-60db5fd84ad443f9a385a12996f9f8d8
Source dataset
uspto-grants-1989_01
Patent number
US04797397

Reaction notes

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