反应详情

1-(2-Chloro-4-nitrophenyl)-4-(4-nitrophenethyl)piperazine (1.0 g), stannous chloride dihydrate (5.7 g) and ethanol (50 ml) were stirred under reflux for 1.25 hours, the mixture was evaporated to low bulk, and added to aqueous 5% sodium hydroxide (100 ml). The mixture was then extracted three times with dichloromethane and the combined organic extracts were dried (sodium sulphate) and evaporated to yield a yellow oil which solidified: yield of the title compound 0.6 g, m.p. 109°-112°. It was used in the next stage without further purification.

1. temperatureunder reflux for 1.25 hours
2. customthe mixture was evaporated to low bulk
3. additionadded to aqueous 5% sodium hydroxide (100 ml)
4. extractionThe mixture was then extracted three times with dichloromethane
5. dry with materialthe combined organic extracts were dried (sodium sulphate)
6. customevaporated
7. customto yield a yellow oil which