1-(2-Chloro-4-nitrophenyl)-4-(4-nitrophenethyl)piperazine → 4-[4-[2-(4-Aminophenyl)ethyl]-1-piperazinyl]-3-chlorobenzenamine

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Reaction Steps

1-(2-Chloro-4-nitrophenyl)-4-(4-nitrophenethyl)piperazine (1.0 g), stannous chloride dihydrate (5.7 g) and ethanol (50 ml) were stirred under reflux for 1.25 hours, the mixture was evaporated to low bulk, and added to aqueous 5% sodium hydroxide (100 ml). The mixture was then extracted three times with dichloromethane and the combined organic extracts were dried (sodium sulphate) and evaporated to yield a yellow oil which solidified: yield of the title compound 0.6 g, m.p. 109°-112°. It was used in the next stage without further purification.

Provenance & Evidence