Methanesulfonyl chloride → 1-(2-Chloro-4-methanesulphonamidophenyl)-4-(4-methanesulphonamidophenethyl)piperazine

HRID 2291560Notes

Reaction equation

HRID 2291560 reaction equation
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:12]=[CH:11][C:10]([N:13]2[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]3[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=3)[CH2:15][CH2:14]2)=[C:9]([Cl:28])[CH:8]=1>N1C=CC=CC=1>[Cl:28][C:9]1[CH:8]=[C:7]([NH:6][S:2]([CH3:1])(=[O:4])=[O:3])[CH:12]=[CH:11][C:10]=1[N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([NH:27][S:2]([CH3:1])(=[O:4])=[O:3])=[CH:23][CH:22]=2)[CH2:15][CH2:14]1

Participants

4

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 212789054-[4-[2-(4-Aminophenyl)ethyl]-1-piperazinyl]-3-chlorobenzenamine

Product 1

HCID 212789151-(2-Chloro-4-methanesulphonamidophenyl)-4-(4-methanesulphonamidophenethyl)piperazineYield 64.2%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The title compound (0.52 g), was prepared similarly to the procedure of Example 1(C) from methanesulphonyl chloride (0.44 g), 1-(4-amino-2-chlorophenyl)-4-(4-aminophenethyl)piperazine (0.55 g), and pyridine (10 ml).

Sources & evidence

ORD record
ord-63693c7948bb4a5c9127d8fc249a2861
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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