Hydrochloric Acid → HCID 21278920, compound

Participants

Reaction Steps

1-Acetyl-4-(3-fluoro-4-nitrophenyl)piperazine (1.08 g), and 2N hydrochloric acid (20 ml) were refluxed for 30 minutes. The solution was then evaporated to dryness, the residue triturated with methanol, the whole re-evaporated to remove hydrochloric acid, and the residue crystallized from methanol/ethanol, yielding the title compound, (0.78 g), m.p. 271°-3°.

Provenance & Evidence