Hydrochloric Acid → HCID 21278920, compound

HRID 2291561Notes

Reaction equation

HRID 2291561 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-:18])=[O:17])=[C:12]([F:19])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:20]>>[ClH:20].[F:19][C:12]1[CH:11]=[C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)[CH:15]=[CH:14][C:13]=1[N+:16]([O-:18])=[O:17]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21278913HCID 21278913, compound

Product 1

HCID 21278920HCID 21278920, compound

Procedure

1-Acetyl-4-(3-fluoro-4-nitrophenyl)piperazine (1.08 g), and 2N hydrochloric acid (20 ml) were refluxed for 30 minutes. The solution was then evaporated to dryness, the residue triturated with methanol, the whole re-evaporated to remove hydrochloric acid, and the residue crystallized from methanol/ethanol, yielding the title compound, (0.78 g), m.p. 271°-3°.

Workup

  1. customThe solution was then evaporated to dryness
  2. customthe residue triturated with methanol
  3. customthe whole re-evaporated
  4. customto remove hydrochloric acid
  5. customthe residue crystallized from methanol/ethanol

Sources & evidence

ORD record
ord-3bd31dac7702471389119a8473a6a6bd
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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