HCID 21278917, compound → HCID 21278923, compound

HRID 2291562Notes

Reaction equation

HRID 2291562 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=3)[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[N+:8]([O-])=O.[H][H]>[Pd]>[F:1][C:2]1[CH:3]=[C:4]([N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([NH2:25])=[CH:23][CH:24]=3)[CH2:13][CH2:12]2)[CH:5]=[CH:6][C:7]=1[NH2:8]

Participants

4

Reactant 2

HCID 21278917HCID 21278917, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 21278923HCID 21278923, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-(3-Fluoro-4-nitrophenyl)-4-(4-nitrophenethyl)piperazine (0.19 g) and 10% palladium on carbon (150 mg) were hydrogenated at 4 atmospheres and 60° until completion of hydrogen uptake. The catalyst was then filtered off, the solvent evaporated, and the residual product (0.06 g) used directly in the next stage.

Workup

  1. filtrationThe catalyst was then filtered off
  2. customthe solvent evaporated

Sources & evidence

ORD record
ord-32797d31e6e5405bbf5bd1e7790d982f
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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