Hydrochloric Acid → HCID 54529973, compound

HRID 2291567Notes

Reaction equation

HRID 2291567 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[C:12]([CH3:21])[CH:11]=2)[CH2:6][CH2:5]1)(=O)C.Cl>>[CH3:20][S:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:11][C:12]=1[CH3:21])(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21278904HCID 21278904, compound

Product 1

HCID 54529973HCID 54529973, compoundYield 93.2%

Procedure

1-Acetyl-4-(4-methanesulphonamido-3-methylphenyl)piperazine (5.93 g) and 2N aqueous hydrochloric acid (85 ml) were refluxed for 2 hours, cooled, evaporated to low bulk, basified with sodium carbonate to pH 9-10 and extracted with 5×100 ml 5% methanol in dichloromethane. The organic layers were combined and evaporated to give the title compound as a brown foam, (4.78 g), m.p. 79°-81°.

Workup

  1. temperaturecooled
  2. customevaporated to low bulk
  3. extractionextracted with 5×100 ml 5% methanol in dichloromethane
  4. customevaporated

Sources & evidence

ORD record
ord-b04bc5d87aef4a85979f86901be91526
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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