反应详情

1-Acetyl-4-(4-methanesulphonamido-3-methylphenyl)piperazine (5.93 g) and 2N aqueous hydrochloric acid (85 ml) were refluxed for 2 hours, cooled, evaporated to low bulk, basified with sodium carbonate to pH 9-10 and extracted with 5×100 ml 5% methanol in dichloromethane. The organic layers were combined and evaporated to give the title compound as a brown foam, (4.78 g), m.p. 79°-81°.

1. temperaturecooled
2. customevaporated to low bulk
3. extractionextracted with 5×100 ml 5% methanol in dichloromethane
4. customevaporated