HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[4-(4-Acetylpiperazin-1-yl)phenyl]methanesulfonamide | HCID 21278916 | — |
| Product | N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride | HCID 18759927 | — |
Reaction Steps
1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797401 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-dc7e346d058b47e6802b42e091e5a229 |
| Source note | uspto-grants-1989_01 |