反应详情

1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).

1. customthe solvent was evaporated
2. customthe residue dried
3. customby azeotroping with toluene
4. customThe residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.)