Hydrochloric Acid → N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

HRID 2291572Notes

Reaction equation

HRID 2291572 reaction equation
C([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:21]>>[ClH:21].[CH3:20][S:17]([NH:16][C:13]1[CH:12]=[CH:11][C:10]([N:7]2[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]2)=[CH:15][CH:14]=1)(=[O:18])=[O:19]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21278916N-[4-(4-Acetylpiperazin-1-yl)phenyl]methanesulfonamide

Product 1

HCID 18759927N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride

Procedure

1-Acetyl-4-(4-methanesulphonamidophenyl)piperazine (9.6 g) and 5N aqueous hydrochloric acid (100 ml) were heated at 100° for 1 hour, the solvent was evaporated, and the residue dried by azeotroping with toluene. The residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.).

Workup

  1. customthe solvent was evaporated
  2. customthe residue dried
  3. customby azeotroping with toluene
  4. customThe residue was crystallised from ethanol, yield of the title compound 8.26 g, m.p. 230° (dec.)

Sources & evidence

ORD record
ord-dc7e346d058b47e6802b42e091e5a229
Source dataset
uspto-grants-1989_01
Patent number
US04797401

Reaction notes

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