Methanol → 1-(4-Methanesulphonamidophenyl)-4-(4-methanesulphonamidophenacyl)piperazine

Participants

Role	Name	HCID	Charge
Reactant	Methanol	HCID 887	—
Reactant	Triethylamine	HCID 8471	—
Reactant	N-(4-(2-bromoacetyl)phenyl)methanesulfonamide	HCID 15592151	—
Reactant	N-[4-(piperazin-1-yl)phenyl]methanesulfonamide hydrochloride	HCID 18759927	—
Solvent	Dichloromethane	HCID 6344	—
Product	1-(4-Methanesulphonamidophenyl)-4-(4-methanesulphonamidophenacyl)piperazine	HCID 21278919	—

Reaction Steps

1-(4-Methanesulphonamidophenyl)piperazine hydrochloride (1.18 g), 4-methanesulphonamidophenacyl bromide (1.16 g), [see J. Med. Chem, 9, 88 (1966)], triethylamine (0.82 g), methanol (10 ml) and dichloromethane (10 ml) were warmed briefly to attain homogeneity, then stirred at ambient temperature for 4 hours, evaporated to dryness, the residue triturated and washed with water, and then crystallized from methanol/acetone. The yield of the title compound was 0.88 g, m.p. 222°-5° (dec.).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04797401
Source dataset	uspto-grants-1989_01
ORD ID	ord-e2d6cdb159b0419a8276e343ac317540
Source note	uspto-grants-1989_01