反应详情

1-(4-Methanesulphonamidophenyl)piperazine hydrochloride (1.18 g), 4-methanesulphonamidophenacyl bromide (1.16 g), [see J. Med. Chem, 9, 88 (1966)], triethylamine (0.82 g), methanol (10 ml) and dichloromethane (10 ml) were warmed briefly to attain homogeneity, then stirred at ambient temperature for 4 hours, evaporated to dryness, the residue triturated and washed with water, and then crystallized from methanol/acetone. The yield of the title compound was 0.88 g, m.p. 222°-5° (dec.).

1. customevaporated to dryness
2. customthe residue triturated
3. washwashed with water
4. customcrystallized from methanol/acetone