Methyl 3-(4-chlorophenyl)-2,2dimethoxypropionate → Methyl 3-(4-chlorophenyl)propanoate

HRID 2291626Notes

Reaction equation

HRID 2291626 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](OC)(OC)[C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1>C(O)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 14373506Methyl 3-(4-chlorophenyl)-2,2dimethoxypropionate

Product 1

HCID 8027172Methyl 3-(4-chlorophenyl)propanoate

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
67.5 °C

Procedure

A mixture of methyl 3-(4-chlorophenyl)-2,2dimethoxypropionate (6.09 g) and formic acid (27 ml) was heated at 65 to 70° C. for 4 hours with stirring. The reaction mixture was cooled and extracted with methylene chloride. The extract was washed with water, dried over magnesium sulfate and evaporated in vacuo to give methyl 3-(4-chlorophenyl)propionate.

Workup

  1. temperatureThe reaction mixture was cooled
  2. extractionextracted with methylene chloride
  3. washThe extract was washed with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

Sources & evidence

ORD record
ord-b0a0b699160f451d82b3c43b272f182a
Source dataset
uspto-grants-1989_01
Patent number
US04797417

Reaction notes

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