Isobutyl 3,4-epoxybutyrate → HCID 86742670, compound

HRID 2291688Notes

Reaction equation

HRID 2291688 reaction equation
[C:1]1([CH:7]2[NH:11][C:10](=[O:12])[CH2:9][NH:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[O:13]1[CH2:23][CH:14]1[CH2:15][C:16]([O:18][CH2:19][CH:20]([CH3:22])[CH3:21])=[O:17]>O.CC(C)=O>[CH3:19][CH:20]([CH3:22])[CH2:21][N:8]1[CH2:9][C:10](=[O:12])[NH:11][CH:7]1[C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1.[OH:13][CH:14]([CH3:23])[CH2:15][C:16]([O-:18])=[O:17]

Participants

5

Reactant 2

HCID 5463767Isobutyl 3,4-epoxybutyrateHCID 21279288HCID 21279288, compound

Product 1

HCID 86742670HCID 86742670, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A mixture of 0.7 g 2-phenylimidazolidine-4-one and 1 g 2-methylpropyl 3,4-epoxybutanoate are heated for 12 h at 70° (external temperature) in 2 ml water and 2 ml acetone. After evaporating, the residue is taken up with ether and the white solid obtained is filtered, and recrystallised from ethyl/acetate, 2-Methylpropyl-2-phenyl-4-oxoimidazolidine-β-hydroxybutanoate is obtained as a white powder, m.p. 126°-128° C.

Workup

  1. customAfter evaporating
  2. customthe white solid obtained
  3. filtrationis filtered
  4. customrecrystallised from ethyl/acetate

Sources & evidence

ORD record
ord-6b19086af7304fcfbbdba0b6ab98f5fe
Source dataset
uspto-grants-1989_01
Patent number
US04797496

Reaction notes

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