HCID 86742670, compound → Oxiracetam

HRID 2291689Notes

Reaction equation

HRID 2291689 reaction equation
CC(C)C[N:4]1[CH2:8][C:7](=[O:9])[NH:6]C1C1C=CC=CC=1.[OH:17][CH:18]([CH3:23])[CH2:19][C:20]([O-:22])=O>CS(C)=O.O>[CH2:19]1[C:20](=[O:22])[N:4]([CH2:8][C:7]([NH2:6])=[O:9])[CH2:23][CH:18]1[OH:17]

Participants

4

Reactant 1

HCID 86742670HCID 86742670, compound

Product 1

HCID 4626Oxiracetam

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 962WaterSolvent

Procedure

A solution of 0.65 g 2-methylpropyl 2-phenyl-4-oxoimidazolidine-β-hydroxybutanoate in 1.5 ml dimethyl sulfoxide and 0.5 ml water is heated at reflux for 16 h. After evaporating, the residue is chromatographed on silica, eluting with 7:3 ethyl acetate/methanol. Oxiracetam is obtained as a white powder, m.p. 167°-70° C.

Workup

  1. temperatureat reflux for 16 h
  2. customAfter evaporating
  3. customthe residue is chromatographed on silica
  4. washeluting with 7:3 ethyl acetate/methanol

Sources & evidence

ORD record
ord-070c1b7e2889487fa5f939515b7fc1bb
Source dataset
uspto-grants-1989_01
Patent number
US04797496

Reaction notes

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