N'-hydroxy-2-phenylethanimidamide → 5-Pentafluoroethyl-4-phenyl-3-aminoisoxazole

HRID 2291703Notes

Reaction equation

HRID 2291703 reaction equation
[C:1]1([CH2:7][C:8](=[N:10][OH:11])[NH2:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:12][C:13]([F:25])([F:24])[C:14]([F:23])([F:22])[C:15](OC(C)(C)C)=O>>[F:22][C:14]([F:23])([C:15]1[O:11][N:10]=[C:8]([NH2:9])[C:7]=1[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:13]([F:25])([F:24])[F:12]

Participants

3

Reactant 2

HCID 2731007N'-hydroxy-2-phenylethanimidamideHCID 2773453tert-Butyl pentafluoropropionate

Product 1

HCID 156139065-Pentafluoroethyl-4-phenyl-3-aminoisoxazole

Procedure

The title compouhd was obtained according to the same procedure as described in Example 32 except that phenylacetoamide oxime (1.50 g, 0.0100 mole) and t-butyl pentafluoropropionate (6.66 g, 0.0300 mole) were used.

Workup

  1. customThe title compouhd was obtained

Sources & evidence

ORD record
ord-fe478da9e98a4737b8e28104d204f796
Source dataset
uspto-grants-1989_01
Patent number
US04797492

Reaction notes

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