Hydrochloric Acid → 5-(Trifluoromethyl)isoxazol-3-ylamine

HRID 2291709Notes

Reaction equation

HRID 2291709 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH:8]C(=O)C)[CH:4]=1.Cl>C(O)CO>[F:1][C:2]([F:13])([F:12])[C:3]1[O:7][N:6]=[C:5]([NH2:8])[CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 212792665-Trifluoromethyl-3-acetylaminoisoxazole

Product 1

HCID 156138795-(Trifluoromethyl)isoxazol-3-ylamine

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

The reaction was carried out according to the same procedure as described in Example 50 except that 5-trifluoromethyl-3-acetylaminoisoxazole (2.21 g, 11.4 mmole), 36% hydrochloric acid (2.89 g, 28.5 mmole) and ehtylene glycol (11.4 ml) were used. The product was then purified by column chromatography on silica gel and further distilled under reduced pressure to give the title compound. Yield: 1.22 g (70.4%), b.p. 84°-85° C./13.0 mmHg.

Workup

  1. customThe product was then purified by column chromatography on silica gel
  2. distillationfurther distilled under reduced pressure

Sources & evidence

ORD record
ord-b16fdf4684a24f6ca2d8325886bfd4fa
Source dataset
uspto-grants-1989_01
Patent number
US04797492

Reaction notes

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