HRID2291750

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID176

Acetic Acid

C2H4O2

HCID71098

D-Tyrosine

C9H11NO3

结构：Cc1cc(O)cc(C)c1C[C@H](NC(=O)OC(C)(C)C)C(=O)N[C@H](C)C(=O)NCCCc1ccccc1

HCID13656661

未命名化合物

HCID20443148

1,4-Dioxane hydrochloride

C4H9ClO2

PRODUCTS

生成物

结构：CCCCNC(=O)Oc1cc(C)c(C[C@H](N)C(=O)N[C@H](C)C(=O)NCCCc2ccccc2)c(C)c1.Cl

HCID131715818

未命名化合物

PROCEDURE

实验过程

The Boc-precursor of the titled compound is prepared by the method of Example 6 using N[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide in place of its D-tyrosine containing analog. The resulting Boc-precursor is reacted with glacial acetic acid and 6.8N HCl-dioxane according to the method of Example 3 to produce the titled hydrochloride salt.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9ff3a9e10b24406ab67cd1b2056f5e3d
来源数据集: uspto-grants-1989_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04797470
来源说明: uspto-grants-1989_01

反应 SMILES

CC(C)(OC([NH:7][C@H:8]([C:19]([NH:21][C@@H:22]([C:24]([NH:26][CH2:27][CH2:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:25])[CH3:23])=[O:20])[CH2:9][C:10]1[C:15]([CH3:16])=[CH:14]C(O)=C[C:11]=1[CH3:18])=O)C.[NH2:37][C@@H:38](C(O)=O)[CH2:39][C:40]1C=CC(O)=C[CH:41]=1.[ClH:50].O1[CH2:56][CH2:55][O:54][CH2:53]C1.C(O)(=[O:59])C>>[ClH:50].[CH2:38]([NH:37][C:53]([O:54][C:55]1[CH:56]=[C:11]([CH3:18])[C:10]([CH2:9][C@@H:8]([C:19]([NH:21][C@@H:22]([C:24]([NH:26][CH2:27][CH2:28][CH2:29][C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)=[O:25])[CH3:23])=[O:20])[NH2:7])=[C:15]([CH3:16])[CH:14]=1)=[O:59])[CH2:39][CH2:40][CH3:41]