HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → O-[(butylamino)carbonyl]-2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide, monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | D-Tyrosine | HCID 71098 | — |
| Reactant | N-[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-tyrosyl-N-(3-phenylpropyl)-D-alaninamide | HCID 13656661 | — |
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Product | O-[(butylamino)carbonyl]-2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide, monohydrochloride | HCID 131715818 | — |
Reaction Steps
The Boc-precursor of the titled compound is prepared by the method of Example 6 using N[(1,1-dimethylethoxy)carbonyl]-2,6-dimethyl-L-tyrosyl-N-(3-phenylpropyl)-D-alaninamide in place of its D-tyrosine containing analog. The resulting Boc-precursor is reacted with glacial acetic acid and 6.8N HCl-dioxane according to the method of Example 3 to produce the titled hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04797470 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-9ff3a9e10b24406ab67cd1b2056f5e3d |
| Source note | uspto-grants-1989_01 |