Sodium Acetate → HCID 13730721, compound

HRID 2291783Notes

Reaction equation

HRID 2291783 reaction equation
[C:1]([C:3]([NH:8][C:9](=[O:15])/[CH:10]=[CH:11]\[C:12]([OH:14])=O)([CH3:7])[CH:4]([CH3:6])[CH3:5])#[N:2].C([O-])(=O)C.[Na+]>C(OC(=O)C)(=O)C>[CH:4]([C:3]([CH3:7])([N:8]1[C:9](=[O:15])[CH:10]=[CH:11][C:12]1=[O:14])[C:1]#[N:2])([CH3:6])[CH3:5]

Participants

4

Reactant 2

HCID 517045Sodium AcetateHCID 86741235HCID 86741235, compound

Product 1

HCID 13730721HCID 13730721, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

A solution of N-(1-cyano-1,2-dimethylpropyl)maleamic acid (595 g, 2.83 mol) in acetic anhydride (3.96 liters) containing sodium acetate (13.72 g, 0.167 mol) is heated under reflux for one hour, cooled and the solvent removed in vacuo. The product is distilled* at 120°-130° C./0.1 mm to give 337 g (63%) of product.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for one hour
  3. temperaturecooled
  4. customthe solvent removed in vacuo
  5. customis distilled* at 120°-130° C.

Sources & evidence

ORD record
ord-3c97682a5ab14101b8d46ba7bbbf5ee1
Source dataset
uspto-grants-1989_01
Patent number
US04798619

Reaction notes

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