Diethyl Ether → Methyl 5-fluoropyridine-2-carboxylate

Temperature

-3 °C

The methyl 5-aminopicolinate (2.2 g) is dissolved in 5.5 ml 48% fluoroboric acid and 20 ml 95% ethanol. The mixture is cooled, with stirring, to -3° C. and then 1.81 g n-butyl nitrite added dropwise. After a further one-half hour at -3° C., 0.5 ml n-butyl nitrite is added slowly and stirring continued for one-half hour at 0° C. After adding 20 ml ether carefully, the mixture is rapidly filtered, and the solid washed twice with cold hexane. The solid is suspended in 100 ml heptane, and the suspension slowly heated with stirring. At about 60° C., a vigorous exothermic reaction occurs. Heating is then continued to 80° C. A red oil separates on the sides of the flask. The heptane solution is filtered, and the filtrate concentrated to give the desired product. The red oil is dissolved in water, excess sodium bicarbonate solution added, and the solution extracted with ethyl acetate. The ethyl acetate extract is washed with saturated brine, dried and concentrated. The residue is chromatographed on silica gel and the product, methyl 5-fluoropicolinate, eluted with 1:1-ether:hexane. This material is used directly for the preparation of the picolinic acid.

1. temperatureThe mixture is cooled
2. waitAfter a further one-half hour at -3° C.
3. stirringstirring
4. waitcontinued for one-half hour at 0° C
5. filtrationthe mixture is rapidly filtered
6. washthe solid washed twice with cold hexane
7. temperaturethe suspension slowly heated
8. stirringwith stirring
9. customAt about 60° C., a vigorous exothermic reaction
10. temperatureHeating
11. customis then continued to 80° C
12. filtrationThe heptane solution is filtered
13. concentrationthe filtrate concentrated

ORD record

ord-d1a9deb2b4ee47b681d26f9a87b3c545

Source dataset

uspto-grants-1989_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04798619