反应详情

A solution of 2-[(1-carbamoyl-1,2-dimethylpropyl)carbamoyl]-3-quinolinecarboxylic acid (0.152 mol), in water (50 ml) containing sodium hydroxide (0.06 mol) is heated at 75° to 80° C. for 2 hours. The solution is cooled in an ice bath and acidified with concentrated hydrochloric acid, added in small increments. The resulting precipitate is filtered, washed with water, air dried, and recrystallized from acetone to afford the 2-(4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl)-3-quinolinecarboxylic acid, mp 239°-243.5° C.

1. temperatureis heated at 75° to 80° C. for 2 hours
2. temperatureThe solution is cooled in an ice bath
3. additionadded in small increments
4. filtrationThe resulting precipitate is filtered
5. washwashed with water, air
6. customdried
7. customrecrystallized from acetone