Hexane → HCID 23711213, compound

HRID 2291822Notes

Reaction equation

HRID 2291822 reaction equation
[C:1]([C:4]1[CH:27]=[CH:26][C:7]([O:8][CH2:9][C:10]2[C:15]3=[N:16][CH:17]=[C:18]([CH2:21][CH2:22][C:23]([OH:25])=[O:24])[C:19](=[O:20])[N:14]3[CH:13]=[CH:12][CH:11]=2)=[C:6]([CH2:28][CH2:29][CH3:30])[C:5]=1[OH:31])(=[O:3])[CH3:2].[OH-].[K+:33].CCCCCC>C(O)C>[K+:33].[C:1]([C:4]1[CH:27]=[CH:26][C:7]([O:8][CH2:9][C:10]2[C:15]3=[N:16][CH:17]=[C:18]([CH2:21][CH2:22][C:23]([O-:25])=[O:24])[C:19](=[O:20])[N:14]3[CH:13]=[CH:12][CH:11]=2)=[C:6]([CH2:28][CH2:29][CH3:30])[C:5]=1[OH:31])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 8058HexaneHCID 14797Potassium HydroxideHCID 30869484H-Pyrido(1,2-a)pyrimidine-3-propanoic acid, 9-((4-acetyl-3-hydroxy-2-propylphenoxy)methyl)-4-oxo-

Product 1

HCID 23711213HCID 23711213, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.50 g (1.18 mmoles) of 3-[9-(4-acetyl-3-hydroxy-2-n-propylphenoxymethyl)-4-oxo-pyrido[1,2-a]pyrimidin-3yl]propionic acid was suspended in 20 ml of ethanol, and 3.90 ml (1.18 mmoles) of a 2% ethanolic solution of potassium hydroxide was added thereto. This suspension was stirred until a clear solution was obtained. To the resulting reaction solution was added a small amount of n-hexane. The solid matter which separated out was collected by filtration and then dried to obtain 0.40 g (73% yield) of 3-[9-(4-acetyl-3-hydroxy-2-n-propyl-phenoxymethyl)-4-oxo-pyrido[1,2-a]pyrimidin-3-yl]propionic acid potassium salt in the form of white powder.

Workup

  1. customwas obtained
  2. customTo the resulting reaction solution
  3. customThe solid matter which separated out
  4. filtrationwas collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-aacae987a74440898b5be217cec4c00d
Source dataset
uspto-grants-1989_01
Patent number
US04798832

Reaction notes

Loading…