HCID 14408832, compound → 99776-29-1

HRID 2291856Notes

Reaction equation

HRID 2291856 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[CH2:11]/[CH:12]=[CH:13]\[CH2:14][OH:15])=[C:4](Cl)[N:3]=1.C(O)=[O:18].O>>[OH:15][CH2:14]/[CH:13]=[CH:12]\[CH2:11][N:8]1[CH:7]=[N:6][C:5]2[C:4](=[O:18])[NH:3][C:2]([NH2:1])=[N:10][C:9]1=2

Participants

3

Reactant 2

HCID 14408832HCID 14408832, compoundHCID 18673298Formic acid--water (1/1)

Product 1

HCID 13551478899776-29-1

Procedure

cis-4-(2-Amino-6-chloropurin-9-yl)-2-buten-1-ol (50 mg) in formic acid-water 7+3 (5 ml) was heated at 45° C. under a nitrogen atmosphere for 20 hours. The solvent was evaporated in vacuum and the residue was dried. Water (0.5 ml) was added and the solution was neutralized with aqueous ammonia. The precipitate was filtered, washed with water, ethanol and ether, and dried to give the compound cis-9-(4-hydroxy-2-butenyl)guanine (40 mg).

Workup

  1. customThe solvent was evaporated in vacuum
  2. customthe residue was dried
  3. additionWater (0.5 ml) was added
  4. filtrationThe precipitate was filtered
  5. washwashed with water, ethanol and ether
  6. customdried

Sources & evidence

ORD record
ord-358c8e3f071147a091b449f9e5cd84ae
Source dataset
uspto-grants-1989_01
Patent number
US04798833

Reaction notes

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