Potassium thiocyanate → HCID 178489846, compound

HRID 2291874Notes

Reaction equation

HRID 2291874 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11](=O)[CH2:12][NH2:13])=[CH:6][CH:5]=1.[S-:15][C:16]#[N:17].[K+]>C(O)(=O)C.O>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]2[N:17]=[C:16]([SH:15])[NH:13][CH:12]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 516872Potassium thiocyanateHCID 85594591HCID 85594591, compound

Product 1

HCID 178489846HCID 178489846, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 3-(4-methoxyphenyl)-2-oxo-1-aminopropane, hydrochloride (3.0 g, 14 mmole) and potassium thiocyanate (1.36 g, 14 mmole) in acetic acid (60 ml) was heated under reflux for 15 minutes. The reaction was cooled, diluted with water and the product was filtered and recrystallized from ethyl alcohol and dried to give the product was a solid (1.6 g, 52%).

Workup

  1. temperatureunder reflux for 15 minutes
  2. temperatureThe reaction was cooled
  3. filtrationthe product was filtered
  4. customrecrystallized from ethyl alcohol
  5. customdried
  6. customto give the product

Sources & evidence

ORD record
ord-d4ae76cd6a5b4abb88caa831fdba5675
Source dataset
uspto-grants-1989_01
Patent number
US04798843

Reaction notes

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