Potassium thiocyanate → HCID 178490006, compound

HRID 2291876Notes

Reaction equation

HRID 2291876 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12](=O)[CH2:13][NH2:14])=[CH:6][CH:5]=1.[S-:16][C:17]#[N:18].[K+]>C(O)(=O)C.O>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][C:12]2[NH:18][C:17]([SH:16])=[N:14][CH:13]=2)=[CH:6][CH:5]=1

Participants

5

Reactant 2

HCID 516872Potassium thiocyanateHCID 131715821HCID 131715821, compound

Product 1

HCID 178490006HCID 178490006, compoundYield 19.2%

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 962WaterSolvent

Procedure

A solution of 4-(4-methoxyphenyl)-2-oxo-1-aminobutane, hydrochloride (8.6 g, 37.7 mmole) and potassium thiocyanate (3.6 g, 37.7 mmole) in acetic acid (100 ml) was heated under reflux for 20 minutes. The reaction was cooled, diluted with water and the product was filtered and recrystallized from ethyl alcohol and dried to give the product as a solid (1.7 g, 19%).

Workup

  1. temperatureunder reflux for 20 minutes
  2. temperatureThe reaction was cooled
  3. filtrationthe product was filtered
  4. customrecrystallized from ethyl alcohol
  5. customdried

Sources & evidence

ORD record
ord-82cbcc68216644058c019003439d1711
Source dataset
uspto-grants-1989_01
Patent number
US04798843

Reaction notes

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