反应详情

1-[5-Acetoxy-2-(phenylethynyl)phenyl]-2-propanone (3.3 g, 11 mmole) was dissolved in MeOH (15 mL) and treated with 50% sodium hydroxide solution (1.8 g, 22 mmole) under argon. The reaction was stirred for 1 hr then poured into dilute hydrochloric acid and extracted with diethyl ether. The combined organic extracts were washed with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated. The product was dried under vacuum to yield 2.78 g (98%) of the title compound.

1. extractionextracted with diethyl ether
2. washThe combined organic extracts were washed with water and brine
3. dry with materialdried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe product was dried under vacuum