Triethylamine → HCID 10361139, compound

HRID 2291917Notes

Reaction equation

HRID 2291917 reaction equation
[Br:1][CH:2]([CH3:6])[C:3](Cl)=[O:4].[CH3:7][O:8][C:9]1[CH:21]=[CH:20][CH:19]=[CH:18][C:10]=1[O:11][CH2:12][CH:13]1[NH:17][CH2:16][CH2:15][S:14]1.C(N(CC)CC)C>C(Cl)Cl>[Br:1][CH:2]([CH3:6])[C:3]([N:17]1[CH2:16][CH2:15][S:14][CH:13]1[CH2:12][O:11][C:10]1[CH:18]=[CH:19][CH:20]=[CH:21][C:9]=1[O:8][CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 979802-Bromopropanoyl chlorideHCID 30254542-[(2-Methoxyphenoxy)methyl]-1,3-thiazolidine

Product 1

HCID 10361139HCID 10361139, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

α-Bromopropionylchloride (0.97 ml) in methylene chloride (15 ml) is added dropwise to a mixture of 2-(o-methoxyphenoxy)methyl-thiazolidine (2 g) and triethylamine (1.35 ml) in CH2Cl2 (30 ml) at 0°-5° C. After 1 hour, the mixture is washed with water and the usual work-up gives 3-α-bromopropionyl-2-(o-methoxyphenoxy)methyl-thiazolidine as a colourless oil.

Workup

  1. washthe mixture is washed with water

Sources & evidence

ORD record
ord-151f8167a1304aeda2cf69b91b41e506
Source dataset
uspto-grants-1989_01
Patent number
US04798898

Reaction notes

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