Hydroxyamine hydrochloride → HCID 86742103, compound

HRID 2291921Notes

Reaction equation

HRID 2291921 reaction equation
[CH:1]([C:3]1[N:4]([CH2:12][C:13]#[CH:14])[CH:5]=[CH:6][C:7]=1[C:8]([O:10][CH3:11])=[O:9])=O.Cl.[NH2:16][OH:17]>N1C=CC=CC=1>[CH2:12]([N:4]1[CH:5]=[CH:6][C:7]([C:8]([O:10][CH3:11])=[O:9])=[C:3]1[CH:1]=[N:16][OH:17])[C:13]#[CH:14]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 13605014HCID 13605014, compound

Product 1

HCID 86742103HCID 86742103, compoundYield 106.9%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

2 g of the product of Step A, 725 mg of hydroxylamine hydrochloride and 11 ml of anhydrous pyridine were stirred for 3 hours at ambient temperature and the pyridine was then concentrated under reduced pressure. The residue was taken up in ethyl acetate and the solution was washed with water, dried and concentrated to obtain 2.3 g of methyl 1-(2-propynyl)-2-oximinomethyl-3-pyrrole-carboxylate melting at 88°-90° C.

Workup

  1. concentrationthe pyridine was then concentrated under reduced pressure
  2. washthe solution was washed with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-b1902dafc1b943f88f9880f07cc67ce6
Source dataset
uspto-grants-1989_01
Patent number
US04798901

Reaction notes

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