Hydrochloric Acid → HCID 19007093, compound

HRID 2291957Notes

Reaction equation

HRID 2291957 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([NH2:20])[CH2:15]3)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[ClH:21]>CO>[ClH:21].[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([N:14]3[CH2:19][CH2:18][CH2:17][CH:16]([NH2:20])[CH2:15]3)(=[O:12])=[O:13])[C:5]=2[CH:4]=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14326747HCID 14326747, compound

Product 1

HCID 19007093HCID 19007093, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 1.0 g of 1-(5-isoquinolinesulfonyl)-3-aminopiperidine. To the solution was added 1N hydrochloric acid so that the pH of the solution became 6.0. Then, the solvent was removed under reduced pressure to obtain a residue. The residue thus obtained was subjected to recrystallization using methanol to obtain 0.81 g of 1-(5-isoquinolinesulfonyl)-3-aminopiperidine hydrochloride.

Workup

  1. customThen, the solvent was removed under reduced pressure
  2. customto obtain a residue
  3. customThe residue thus obtained
  4. customwas subjected to recrystallization

Sources & evidence

ORD record
ord-c0fe96b17c184e41951f2d649f7e6117
Source dataset
uspto-grants-1989_01
Patent number
US04798897

Reaction notes

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