HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2291968Generated: October 29, 2026
4-Chloro-3-nitrophenyl methyl sulfone → 4-(beta,gamma-Dihydroxypropyl)amino-3-nitrophenyl methyl sulfone
https://huagongshe.com/reaction/2291968
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Chloro-3-nitrophenyl methyl sulfone | HCID 66796 | — |
| Reactant | 3-Amino-1,2-propanediol | HCID 73561 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 4-(beta,gamma-Dihydroxypropyl)amino-3-nitrophenyl methyl sulfone | HCID 21277590 | 95% |
Reaction Steps
A mixture of 4-chloro-3-nitrophenyl methyl sulfone (5 g, 21 mmole) and 3-amino-1,2-propanediol (4.25 g, 47 mmole) in DMSO (15 ml) was stirred at 23° C. for 30 min. and poured into crushed ice. The resulting yellow crystal was collected by filtration and washed with ice-cold water to give the compound (21) (5.2 g, 95%) (m.p. 133° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04799934 |
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| Source dataset | uspto-grants-1989_01 |
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| ORD ID | ord-5ce0f537163047d58f2606cb18a53e67 |
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| Source note | uspto-grants-1989_01 |
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