反应详情

温度

23 °C

A mixture of 4-chloro-3-nitrophenyl methyl sulfone (5 g, 21 mmole) and 3-amino-1,2-propanediol (4.25 g, 47 mmole) in DMSO (15 ml) was stirred at 23° C. for 30 min. and poured into crushed ice. The resulting yellow crystal was collected by filtration and washed with ice-cold water to give the compound (21) (5.2 g, 95%) (m.p. 133° C.).

1. additionpoured
2. custominto crushed ice
3. filtrationThe resulting yellow crystal was collected by filtration
4. washwashed with ice-cold water