Thionyl Chloride → HCID 21277812, compound

HRID 2291995Notes

Reaction equation

HRID 2291995 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)O)=[CH:7][C:6]=2[CH:19]=1.S(Cl)([Cl:22])=O>C(Cl)Cl.C1CCCCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH:10]([Cl:22])[C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)=[CH:7][C:6]=2[CH:19]=1

Participants

5

Reactant 2

HCID 24386Thionyl ChlorideHCID 3067877(5-Bromo-1-benzofuran-2-yl)(4-chlorophenyl)methanol

Product 1

HCID 21277812HCID 21277812, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8078CyclohexaneSolvent

Procedure

To 36.2 g of (5-bromobenzofuran-2-yl)(p-chlorophenyl)methanol dissolved in 50 ml of methylenchloride, 8.5 ml of thionylchloride in 25 ml of cyclohexane are added drop by drop, under agitation. After a 4 hour rest at 10° C., the solution is brought to dryness under vacuum condition. The residue is crystallized from petroleum ether: m.p. 83°-85° C.

Workup

  1. customThe residue is crystallized from petroleum ether

Sources & evidence

ORD record
ord-be99d0cd59cb413c8d2f4a1f665f4aba
Source dataset
uspto-grants-1989_01
Patent number
US04800208

Reaction notes

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