Sulfur → HCID 13672413, compound

HRID 2292011Notes

Reaction equation

HRID 2292011 reaction equation
[CH3:1][C:2]1[NH:3][C:4](=[O:24])[CH2:5][S:6][C:7]=1[CH:8]1[CH:13]=[CH:12][N:11](C(OCC(Cl)(Cl)Cl)=O)[CH:10]=[C:9]1[C:22]#[N:23].[S]>>[CH3:1][C:2]1[NH:3][C:4](=[O:24])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][C:9]=1[C:22]#[N:23]

Participants

3

Reactant 2

HCID 5362487SulfurHCID 13672421HCID 13672421, compound

Product 1

HCID 13672413HCID 13672413, compoundYield 10.6%

Procedure

A mixture of 5-methyl-6-[1-(2,2,2-trichloroethoxycarbonyl)-3-cyano-1,4-dihydro-4-pyridinyl]-2H-1,4-thiazin-3(4H)-one (0.5 g) and sulfur sublimed (2.5 g) was treated in the same manner as described in Example 4 (ii) to give the titled compound (0.03 g, yield 10.6%) as pale orange powder. Chloroform-methanol (=20:1) was used as a developing eluant.

Workup

  1. additionwas treated in the same manner

Sources & evidence

ORD record
ord-59280e85cf574096aafb2db1dff824d5
Source dataset
uspto-grants-1989_01
Patent number
US04800201

Reaction notes

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