反应详情

m-Chloroperbenzoic acid (2.8 g) was added to a stirred solution of 2 -methoxy-5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (2.7 g) in methanol (100 ml) under ice/water-cooling. The reaction mixture was further stirred at ambient temperature for 2 hours. Methanol was removed under reduced pressure and the residue was dissolved in ethyl acetate, was washed with saturated sodium bicarbonate aqueous solution and successively with water, and was dried over magnesium sulfate. Ethyl acetate was removed under reduced pressure and the residue was crystallized from ether to give the titled compound (2 g, yield 66.7%) as pale yellow powder.

1. temperaturecooling
2. customMethanol was removed under reduced pressure
3. dissolutionthe residue was dissolved in ethyl acetate
4. washwas washed with saturated sodium bicarbonate aqueous solution and successively with water
5. dry with materialwas dried over magnesium sulfate
6. customEthyl acetate was removed under reduced pressure
7. customthe residue was crystallized from ether