HRID2292068

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2798712

N-[4-(oxiran-2-ylmethoxy)phenyl]acetamide

C11H13NO3

反应SMILES：CCOCCOc1ccc(C[C@@H](C)N(CC(O)COc2ccc(NC(C)=O)cc2)CC(O)c2cccc(Cl)n2)cc1

HCID53790281

未命名化合物

PRODUCTS

产物

反应SMILES：CCOCCOc1ccc(C[C@@H](C)NCC(O)c2cccc(Cl)n2)cc1

HCID54562232

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

using 4'-(2,3-epoxypropoxy)acetanilide there were obtained from 1.0 g of (RS)-6-chloro-α-[[[(R)-p-(2-ethoxyethoxy)-α -methylphenethyl]amino]methyl]-2-pyridinemethanol (Example 4C) 530 mg of 4'-[(RS)-3-[[(RS)-2-(6-chloro-2-pyridyl)-2-hydroxyethyl][(R)-p-(2-ethoxyethoxy)-α-methylphenethyl]amino]-2-hydroxypropoxy]acetanilide, [α]D20° =-39° (c=0.4 in MeOH),