HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-((oxiran-2-yl)methoxy)phenyl)acetamide → (RS)-6-chloro-alpha-[[[(R)-p-(2-ethoxyethoxy)-alpha-methylphenethyl]amino]methyl]-2-pyridinemethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-((oxiran-2-yl)methoxy)phenyl)acetamide | HCID 2798712 | — |
| Reactant | HCID 53790281 | HCID 53790281 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (RS)-6-chloro-alpha-[[[(R)-p-(2-ethoxyethoxy)-alpha-methylphenethyl]amino]methyl]-2-pyridinemethanol | HCID 54562232 | — |
Reaction Steps
using 4'-(2,3-epoxypropoxy)acetanilide there were obtained from 1.0 g of (RS)-6-chloro-α-[[[(R)-p-(2-ethoxyethoxy)-α -methylphenethyl]amino]methyl]-2-pyridinemethanol (Example 4C) 530 mg of 4'-[(RS)-3-[[(RS)-2-(6-chloro-2-pyridyl)-2-hydroxyethyl][(R)-p-(2-ethoxyethoxy)-α-methylphenethyl]amino]-2-hydroxypropoxy]acetanilide, [α]D20° =-39° (c=0.4 in MeOH),
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04800206 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-3a02fec44b0e42619f2aaa90717bfd28 |
| Source note | uspto-grants-1989_01 |