Water → HCID 54526792, 화합물

HRID 2292081노트

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HRID 2292081 반응식
[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:6][C:7]1[CH:14]=[C:12]([I:13])[C:11]([O:15][C:16]2[CH:23]=[C:21]([I:22])[C:20]([OH:24])=[C:18]([I:19])[CH:17]=2)=[C:9]([I:10])[CH:8]=1)[NH2:5].[C:26]([NH:36][CH2:37][C:38]([NH:40][CH2:41][C:42](O)=[O:43])=[O:39])([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27].C1(N=C=NCCN2CCOCC2)CCCCC1.O>CC(N(C)C)=O>[CH3:1][O:2][C:3](=[O:25])[C@H:4]([CH2:6][C:7]1[CH:8]=[C:9]([I:10])[C:11]([O:15][C:16]2[CH:17]=[C:18]([I:19])[C:20]([OH:24])=[C:21]([I:22])[CH:23]=2)=[C:12]([I:13])[CH:14]=1)[NH:5][C:42](=[O:43])[CH2:41][NH:40][C:38](=[O:39])[CH2:37][NH:36][C:26]([O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:27]

참가 물질

6

반응물 4

HCID 962WaterHCID 849981-Cyclohexyl-3-(2-morpholinoethyl)carbodiimideHCID 95686CarbobenzoxyglycylglycineHCID 13911218Methyl O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosinate

생성물 1

HCID 54526792HCID 54526792, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

Thyroxine methyl ester (5 g), as prepared above, N-carbobenzoxyglycylglycine (1.67 g) and cyclohexylmorpholinoethylcarbodiimide (5.3 g) were combined in 40 ml of dimethylacetamide. The mixture was stirred at room temperature for 24 hours, poured into deionized water, and the resulting residue collected and washed with water. The residue was recrystallized from methanol and water, yielding the product, N-carbobenzoxyglycylglycylthyroxine methyl ester.

후처리

  1. customthe resulting residue collected
  2. washwashed with water
  3. customThe residue was recrystallized from methanol and water

출처 및 근거

ORD 기록
ord-4718335ddf224bf8b86e38e3aa468b9c
출처 데이터셋
uspto-grants-1989_01
특허 번호
US04801504

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