HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → N-carbobenzoxyglycylglycylthyroxine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide | HCID 84998 | — |
| Reactant | Carbobenzoxyglycylglycine | HCID 95686 | — |
| Reactant | Methyl O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosinate | HCID 13911218 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | N-carbobenzoxyglycylglycylthyroxine methyl ester | HCID 54526792 | — |
Reaction Steps
Thyroxine methyl ester (5 g), as prepared above, N-carbobenzoxyglycylglycine (1.67 g) and cyclohexylmorpholinoethylcarbodiimide (5.3 g) were combined in 40 ml of dimethylacetamide. The mixture was stirred at room temperature for 24 hours, poured into deionized water, and the resulting residue collected and washed with water. The residue was recrystallized from methanol and water, yielding the product, N-carbobenzoxyglycylglycylthyroxine methyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04801504 |
| Source dataset | uspto-grants-1989_01 |
| ORD ID | ord-4718335ddf224bf8b86e38e3aa468b9c |
| Source note | uspto-grants-1989_01 |